منابع مشابه
Anticancer Drug Discovery — From Serendipity to Rational Design
Cancer is nowadays used as a generic term describing a group of about 120 different diseases, which can affect any part of the body and defined as the state characterized by the uncontrolled growth and invasion of normal tissues and spread of cells [1]. According to WHO reports cancer is a leading cause of premature death worldwide, accounting for 7.6 million deaths (around 13% of all deaths) o...
متن کاملThe role of serendipity in drug discovery
Serendipity is one of the many factors that may contribute to drug discovery. It has played a role in the discovery of prototype psychotropic drugs that led to modern pharmacological treatment in psychiatry. It has also played a role in the discovery of several drugs that have had an impact on the development of psychiatry. "Serendipity" in drug discovery implies the finding of one thing while ...
متن کاملSystematizing serendipity for cardiovascular drug discovery.
Serendipity has played a significant role throughout the history of drug discovery in general and, in particular, throughout the history of cardiovascular medicine. The anticoagulant properties of dicoumarol were discovered after farmers observed that their cattle were dying of internal hemorrhaging after feeding on rotting sweet clover,1 and digitoxin was identified when the condition of a pat...
متن کاملEDITORIALS Anticancer Drug Discovery
The National Cancer Institute's (NCI's) human tumor cell line panel for screening potential new anticancer drugs is now operational (/). Its implementation and the demonstration of its feasibility represent a technical and organizational tour de force. The rationale for the change in the primary screen from leukemias in mice to the array of 60 human cancer cell lines was earlier debated in cont...
متن کاملOn the Exploitation of Serendipity in Drug Discovery
Copyright: © 2013 Baumeister AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. We have written previously about the nature of serendipity and the role that it played in the “Psychopharmacology Revolut...
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ژورنال
عنوان ژورنال: World Journal of Clinical Oncology
سال: 2012
ISSN: 2218-4333
DOI: 10.5306/wjco.v3.i1.1